Pd(II)-Catalyzed C-H Silylation of o-Alkynylanilines Initiated by an Aminopalladation To Access Disilylated 2-Phenyl-1H-indoles

Yan Chen, Ling Zhu, Xuliang Tan,Xiahong Chen,Guobo Deng,Yun Liang,Yuan Yang

ADVANCED SYNTHESIS & CATALYSIS（2024）

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摘要

Herein a Pd(II)-catalyzed C-H silylation of o-alkynylanilines with hexamethyldisilane for the synthesis of disilylated 2-phenyl-1H-indoles is reported. In this reaction, o-alkynylanilines undergo an aminopalladation, C-H activation, and dealkylation sequence to form five-membered C,C-palladacycles, which then couple with hexamethyldisilane to construct one C-N bond and two C-Si bonds. This method provides an alternative strategy for C-H silylation.

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关键词

C,C-palladacycles,C-H silylation,o-alkynylanilines,aminopalladation,disilylated 2-phenyl-1H-indoles

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