Preparation and properties of glycol chitosan based self-healing hydrogel

self-healing oxidized sodium alginate-glycol chitosan hydrogel (OSA-GC) based on dynamic imine bonds was synthesized. Oxidized sodium alginate (OSA) was synthesized by oxidizing sodium alginate with sodium periodate, and self-healing OSA-GC hydrogels with different cross-linking degrees were prepared by Schiff base reaction with glycol chitosan (GC). The effect of GC concentration on the microscopic morphology,viscoelasticity,swelling performance,self-repair performance, degradation rate and in vitro drug release performance of OSA-GC hydrogels were investigated. The results show that OSA-GC hydrogels have the characteristics of porous structure with a pore size ranging from 50 Inm to 280 Inm by controlling the mass ratio of OSA to GC. The OSA-GC hydrogels can reach the swelling equilibrium at 120 hours, and the swelling ratio reach 71. 3-112. 1. OSA-GC hydrogel can be degraded in PBS containing lysozyme (10 mg/mL), and the mass loss of OSA-GC hydrogel is 43. 1%-51. 9% after 12 days. At room temperature, OSA-GC hydrogels can achieve self-healing within 2 h in the absence of external stimuli. OSA-GC hydrogel loaded with gemcitabine shows a sustained release effect on the anticancer drug gemcitabine, and the release time can reach 48 hours in the drug release experiment, which shows promising application prospects in biomedical fields of drug carriers.