Mimic uracil-uracil base pairing: self-assembly and single crystal structure
CRYSTENGCOMM(2024)
摘要
The controllable synthesis of non-classical nucleobase pairs that can mimic partial biological behavior is very important for the in-depth study of DNA or RNA. Here, three different interaction modes of uracil-uracil base pairs (U-motif) have been explored in the coordination complexes of 2 '-deoxyuracil 5 '-monophosphate (dUMP) and uracil 5 '-monophosphate (UMP) with transition metal ions by single crystal structural analysis and DFT calculations for the first time. The results indicate that the structural diversity of non-classical nucleobase pairs may be a bank of supramolecular interactions, which will contribute to the study of supramolecular chemistry and biochemistry. The controllable synthesis of non-classical nucleobase pairs that can mimic partial biological behavior is very important for the in-depth study of DNA or RNA.
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