3D Printed Design-Assisted Multilayered Graphene Oxide-Modified Polymer Glucose Sensor

This work investigates the capabilities of a platform for nonenzymatic glucose sensing employing a novel 3D printed three-electrode mask-embedded design. A reservoir-on-mask has been fabricated for smart sample insertion to avoid spillage. Working and counter silver electrodes are modified with three different material combinations such as graphene oxide (GO), poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), and GO + PEDOT:PSS, and their performance comparison is demonstrated. It is observed that the GO + PEDOT:PSS modification shows 94.57 and 71.01% higher sensitivity than GO and PEDOT:PSS, respectively, including a higher linearity compared to its counterparts. Glucose concentrations ranging from 50 to 300 mg dL-1 are detected by employing cyclic voltammetry and electrical impedance spectroscopic technique. Herein, a significantly high sensitivity of 18.8 mu AmM-1 cm-2 and low limit of detection approximate to 0.4 mM has been achieved for the proposed sensor. The 3D printed mask structure provides 75% higher sample retention ability, greater reliability in terms of sample placement in the sensor and improved test performances. The proposed sensor can provide a stable and large-scale deployable solution to future biosensing platforms. A 3D printed three-electrode mask-embedded design for nonenzymatic glucose sensing is developed with a "reservoir-on-mask" design for sample placement without spillage. Working and counter electrodes are modified with graphene oxide (GO), poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) and GO + PEDOT:PSS. Cyclic voltammetry and electrical impedance spectroscopy study are conducted to observe the device's electrical performance, sensitivity, limit of detection, selectivity, and other parameters.image (c) 2023 WILEY-VCH GmbH