I₂/CAN as a Mild and Efficient Reagent for Oxidative Csp³-Csp² Cleavage of 3,3-Bis-7-azaindolylmethane: A Rapid One-Pot Access to 3-Formyl and 3-Iodo-7-azaindoles

The combination of I-2/CAN has emerged as a mild and powerful reagent for the oxidative Csp(3)-Csp(2) cleavage of 3,3'-bis-7-azaindolylmethane to provide a quantitative combined yield of 3-formyl and 3-iodo-7-azaindole in a one-pot reaction at RT. A plausible mechanism and characterization, including XRD, has been described. The synthetic transformations of title compounds were explored by reduction, Click, reductive amination, and Suzuki coupling reaction.