Efficacy of Transcranial Direct Current Stimulation for Controlling of Food Craving in Subjects With Overweight or Obesity: A Pilot Study

Objective We aim to explore the effects of transcranial direct current stimulation (tDCS) on food craving improvement and changes in brain function associated with craving by conducting a total of 10 sessions of tDCS over a period of 2 weeks on overweight and obese subjects.Methods A total of 15 patients who were overweight or obese (body mass index [BMI] >= 23 kg/m2) were included. Weight, BMI, neuropsychological variables, and food craving-related variables were assessed. We measured absolute and relative power in 19 channels and analyzed quantitative electroencephalography (qEEG) according to the following frequency ranges: delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta (12-25 Hz), high beta (25-30 Hz), and gamma (30-80 Hz).Results After the application of tDCS, there was no significant reduction observed in weight and BMI. However, all measures related to food and eating showed a decrease in the intensity of cravings, and there was also a significant reduction in depression, anxiety, and perceived stress. In qEEG analysis, an increase in theta waves was observed in the left frontal area (F7 and F3), an increase in alpha waves in the right parietal area (P4), and a decrease in beta waves in the frontal area (FP2) and occipital area (O1).Conclusion This study confirmed the beneficial effects of tDCS on food craving regulation in overweight or obese individuals and observed improved scores in psychological factors such as depression and anxiety. Furthermore, neurophysiological changes related to food craving were observed using qEEG. Psychiatry Investig