In vivo techniques for assessment of insulin sensitivity and glucose metabolism
JOURNAL OF ENDOCRINOLOGY(2024)
摘要
Metabolic tests are vital to determine in vivo insulin sensitivity and glucose metabolism in preclinical models, usually rodents. Such tests include glucose tolerance tests, insulin tolerance tests, and glucose clamps. Although these tests are not standardized, there are general guidelines for their completion and analysis that are constantly being refined. In this review, we describe metabolic tests in rodents as well as factors to consider when designing and performing these tests.
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关键词
whole animal physiology,glucose metabolism,insulin sensitivity,glucose tolerance
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