Reduction of intracellular oxidative stress with a copper-incorporated layered double hydroxide

Biocompatible Cu(ii)-doped layered double hydroxide (CMA) nanoparticles were developed to combat reactive oxygen species. The 2-dimensional nanozymes showed both superoxide dismutase- and catalase-like activities in chemical assays, while proving as efficient antioxidants in the reduction of intracellular oxidative stress. The results indicate the great promise of CMA in antioxidant therapies. Structural modification of 2-dimensional clay nanoparticles led to the development of biocompatible antioxidant nanozymes to combat intracellular oxidative stress.