The remission status of AML patients post alloSCT is associated with a distinct single-cell bone marrow T cell signature

Anna Mathioudaki, Xizhe Wang,David Sedloev, Richard Huth, Aryan Kamal,Michael Hundemer,Yi Liu,Spyridoula Vasileiou,Premal Lulla,Carsten Müller-Tidow,Peter Dreger,Thomas Luft,Tim Sauer,Michael Schmitt,Judith B. Zaugg,Caroline Pabst

Blood（2024）

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摘要

1.Distinct scRNA-seq signatures characterize bone marrow T cells of AML patients in remission and with relapse post alloSCT.2.GPR56 increases on the surface of CD8+ T cells post alloSCT and marks allo-reactive, highly cytotoxic T cells recognizing non-self.

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