Lactate administration improves laboratory parameters in murine models of iron overload.

Wei Liu,Yue Wu, Huaiqing Wei,Juan Ma, Wenya Feng, Qiuyuan Yang,Shuping Zhang,Tomas Ganz,Sijin Liu

Blood（2024）

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摘要

ABSTRACT:Current iron overload therapeutics have inherent drawbacks including perpetuated low hepcidin. Here, we unveiled that lactate, a potent hepcidin agonist, effectively reduced serum and hepatic iron levels in mouse models of iron overload with an improved erythropoiesis in β-thalassemic mice.

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