Development and validation of an UPLC-MS/MS method for the determination of irinotecan (CPT-11), SN-38 and SN-38 glucuronide in human plasma and peritoneal tumor tissue from patients with peritoneal carcinomatosis

Elke Gasthuys,Judith van Ovost, Sofie Vande Casteele,Sarah Cosyns,Wim Ceelen,Jan Van Bocxlaer,An Vermeulen

Journal of Chromatography B（2024）

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摘要

•Validated UPLC-MS/MS method in peritoneal tumor tissue for CPT-11 and metabolites.•Cross-validation pilot PK study demonstrated usefulness in clinical settings.•Post-sampling conversion by carboxylesterases is not expected in peritoneal tissue.

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关键词

Irinotecan (CPT-11),SN-38,SN-38 glucuronide,UPLC-MS/MS,Carboxylesterase

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