Implantable Photonic Neural Probes with Out-of-Plane Focusing Grating Emitters
arxiv(2024)
摘要
We have designed, fabricated, and characterized implantable silicon neural
probes with nanophotonic grating emitters that focus the emitted light at a
specified distance above the surface of the probe for spatially precise
optogenetic targeting of neurons. Using the holographic principle, we designed
gratings for wavelengths of 488 and 594 nm, targeting the excitation spectra of
the optogenetic actuators Channelrhodopsin-2 and Chrimson, respectively. The
measured optical emission pattern of these emitters in non-scattering medium
and tissue matched well with simulations. To our knowledge, this is the first
report of focused spots with the size scale of a neuron soma in brain tissue
formed from implantable neural probes.
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