The role of secreted proteins in efferocytosis

Guangsheng Hou, Xinyu Wang, Anhua Wang,Lei Yuan,Qian Zheng,Hui Xiao,Hui Wang

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY(2024)

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摘要
The clearance of apoptotic cells known as efferocytosis is the final stage of apoptosis, and includes the recognition, phagocytosis, and degradation of apoptotic cells. The maintenance of tissue homeostasis requires the daily elimination of billions of apoptotic cells from the human body via the process of efferocytosis. Accordingly, aberrations in efferocytosis underlie a growing list of diseases, including atherosclerosis, cancer, and infections. During the initial phase of apoptosis, "Eat-Me" signals are exposed and recognized by phagocytes either directly through phagocyte receptors or indirectly through secreted proteins that function as bridge molecules that cross-link dying cells to phagocytes. Here, we set out to provide a comprehensive review of the molecular mechanisms and biological significance of secreted proteins in apoptotic cell clearance. Specifically, it focuses on how these secreted proteins act as bridging molecules to facilitate the clearance process.
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关键词
apoptosis,apoptotic cell clearance,efferocytosis,secreted proteins,bridging molecule
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