Biodegradable Microparticles with Encapsulated Anti-Inflammatory Peptide Ingramon

technique for encapsulating the anti-inflammatory dodecapeptide ingramon into microspheres of a biodegradable copolymer of lactic and glycolic acids (PLGA) to provide prolonged release of the peptide for up to 28 d is presented. The technique makes it possible to achieve >90% encapsulation efficiency and is suitable for producing an injectable suspension that meets the requirements of the State Pharmacopoeia of the Russian Federation . The peptide distribution inside the obtained microspheres and its release kinetics were characterized. A tendency toward suppression of JE/CCL2-dependent monocyte migration was revealed in mice with preliminary (7 d before the experiment) administration of ingramon-depot.