Levetiracetam: A Potent Sword against Microglia Polarization in Gliomas

Xiaoteng Cui,Qixue Wang,Xiaomin Liu,Chunsheng Kang

CLINICAL CANCER RESEARCH（2024）

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Abstract

Crosstalk between tumor cells and peritumoral cells contributes to immunosuppressive microenvironment formation in glioblastomas (GBM). A recent study revealed that glioma stem cells activated neuronal activity to promote microglial M2 polarization, leading to GBM progression, which could be pharmacologically blocked by levetiracetam, providing a practical strategy for GBM immunotherapy. See related article by Guo et al., p. 1160

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