Melatonin inhibits the formation of intraplaque neovessels in ApoE−/− mice via PPARγ- RhoA-ROCK pathway

YuFan Jiang,Wei Tong,Yueyang Li,Qiang Ma,YunDai Chen

Biochemical and Biophysical Research Communications（2024）

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摘要

•Melatonin reduces intraplaque neovessels and intraplaque hemorrhage via PPARγ- RhoA-ROCK pathway.•Melatonin inhibits the angiogenic processes of endothelial cells via PPARγ- RhoA-ROCK pathway.•Activation of PPARγ contributes to the suppression of endothelial migration and intraplaque neovessels.

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关键词

Atherosclerosis,Angiogenesis,Intraplaque neovessels,Melatonin,PPARγ

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