Kinetic modeling of chemical processes in the human brain: memory, formation of a neuroimage, and kinetic behavior of the system of synaptic contacts

A kinetic model of functioning of synapses and synaptic circuits responsible for cognitive function was developed. Cholinergic synapse functioning upon a change in the neurotransmitter concentration and acetylcholinesterase activity was analyzed in the framework of this model, and the principles of formation of a “neuroimage” and a “conduction track” in the synaptic system were explained. The effects of signal intensity, impulse frequency, receptor desensitization rate, and acetylcholinesterase expression level were analyzed. The dynamic regularities of the system behavior under constant neuron excitation (variant of stroke and action of nerve agents) were constructed. The kinetic trends upon blocking of acetylcholine receptors by physiologically active compounds and drugs were determined. The kinetic model of the synapse system was modified with involvement of elements of the mathematical theory of neural networks (artificial intelligence) with the definition of “ideal synapse” and “ideal synaptic network”.