An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)

Lai Wei, Shuiqing Liu,Shanshan Lu,Shengdong Luo,Xiaoping An,Huahao Fan,Weiwei Chen,Erguang Li,Yigang Tong,Lihua Song

biorxiv（2024）

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摘要

SARS-CoV-2-related pangolin coronavirus GX\_P2V(short\_3UTR) is highly attenuated, but can cause mortality in a specifically designed human ACE2-transgenic mouse model, making it an invaluable surrogate model for evaluating the efficacy of drugs and vaccines against SARS-CoV-2. ### Competing Interest Statement The authors have declared no competing interest.

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