High risk and silent clonal hematopoietic genotypes in patients with non-hematologic cancer

Aaron J. Stonestrom,Kamal N. Menghrajani,Sean M. Devlin, Sebastià Franch-Expósito, Ryan N. Ptashkin, Swara Y. Patel,Barbara Spitzer, Xiaodi Wu, Justin Jee,Pablo Sánchez-Vela, Jennifer H. Milbank,Ronak H. Shah,Abhinita S. Mohanty,A. Rose Brannon,Wenbin Xiao,Michael F. Berger,Simon Mantha,Ross L. Levine

Blood advances（2023）

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摘要

1.High risk CH mutations in JAK2, RUNX1, and XPO1 anticipate hematologic malignancy in cancer patients2.Functionally neutral silent CH variants are significant predictors of hematologic malignancy risk

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