Thrombin generation on vascular cells in the presence of factor VIII and/or emicizumab

Sénadé Atsou,Célia Schellenberg,Jeremy Lagrange,Patrick Lacolley,Peter J. Lenting, Cécile V. Denis,Olivier D. Christophe,Véronique Regnault

Journal of Thrombosis and Haemostasis（2024）

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Abstract

•Thrombin generation by factor (F) VIII and emicizumab on vascular cells was investigated.•Endothelial and smooth muscle cells support FVIII- and emicizumab-mediated thrombin generation.•Emicizumab activity is limited by an excess of FIX when phospholipids are limiting.•Anticoagulant components play an important role in controlling FVIII and emicizumab activity.

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Key words

emicizumab,endothelial cells,factor VIII,smooth muscle cells,thrombin generation

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