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Association between maternal diet, smoking, and the placenta MTHFR 677C/T genotype and global placental DNA methylation

Hector Diaz-Garcia,Jenny Vilchis-Gil, Karla V. Castro-Cerritos, Luis E. Rivera-Susunaga,Miguel Klünder-Klünder,Javier T. Granados-Riveron,Jaqueline Gómez-López,Adolfo López-Torres,Rocío Sánchez-Urbina

Placenta（2024）

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Abstract
•Maternal coffee intake was associated with changes in the DNA methylation pattern of the placenta.•Maternal smoking in early gestation was associated with decreased placental DNA methylation.•The placental TT genotype of the MTHFR gene and maternal nutrition (folic acid and vegetables) was correlated with changes in the methylation pattern of the placenta.
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Diet,Pregnancy,Placental DNA methylation,MTHFR
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