IL-10 dampens antitumor immunity and promotes liver metastasis via PD-L1 induction

Ahmad Mustafa Shiri,Tao Zhang,Tanja Bedke,Dimitra E. Zazara,Lilan Zhao,Jöran Lücke,Morsal Sabihi,Antonella Fazio, Siwen Zhang,Daniele V.F. Tauriello,Eduard Batlle,Babett Steglich,Jan Kempski,Theodora Agalioti,Mikołaj Nawrocki,Yang Xu,Kristoffer Riecken,Imke Liebold,Leonie Brockmann,Leonie Konczalla

Journal of Hepatology（2023）

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摘要

•IL-10 promotes colorectal cancer-derived liver metastasis•Foxp3+Tregs are the main source of IL-10 during liver metastasis formation•IL-10 acts on myeloid cells thereby dampens antitumor immunity•The effect of IL-10 is at least in part mediated via PD-L1

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关键词

Liver metastasis,IL-10,PD-L1,Immunotherapy,Immune cells

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