IL-10 dampens antitumor immunity and promotes liver metastasis via PD-L1 induction
Journal of Hepatology(2023)
摘要
•IL-10 promotes colorectal cancer-derived liver metastasis•Foxp3+Tregs are the main source of IL-10 during liver metastasis formation•IL-10 acts on myeloid cells thereby dampens antitumor immunity•The effect of IL-10 is at least in part mediated via PD-L1
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关键词
Liver metastasis,IL-10,PD-L1,Immunotherapy,Immune cells
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