Clinical features and neurobiochemical mechanisms of olfactory dysfunction in patients with Parkinson disease

This study aimed to investigate clinical features, influencing factors and neurobiochemical mechanisms of olfactory dysfunction (OD) in Parkinson disease (PD). Total 39 patients were divided into the PD with OD (PD–OD) and PD with no OD (PD–nOD) groups according to overall olfactory function, including threshold, discrimination and identification, assessed by Sniffin’ Sticks test. Motor function and non-motor symptoms were rated by multiple scales. Dopamine, acetylcholine, norepinephrine and 5-hydroxytryptamine levels in cerebrospinal fluid (CSF) were measured. We found that the PD–OD group showed significantly lower score of Montreal Cognitive Assessment Scale, higher scores of rapid eye movement sleep behavior disorder (RBD) Screening Questionnaire and Epworth Sleepiness Scale than the PD–nOD group ( p < 0.05). RBD Screening Questionnaire score was independently associated with the scores of overall olfactory function and discrimination ( p < 0.05). Dopamine and acetylcholine levels in CSF from the PD–OD group was significantly lower than that from the PD–nOD group ( p < 0.05). Dopamine and acetylcholine levels in CSF were significantly and positively correlated with the scores of overall olfactory function, threshold, discrimination and identification in PD patients ( p < 0.05). RBD Screening Questionnaire score was significantly and negatively correlated with acetylcholine level in CSF in PD patients with poor olfactory detection ( p < 0.05). This investigation reveals that PD–OD is associated with cognitive impairment, probable RBD and excessive daytime sleepiness. PD–OD is correlated with the decreased levels of dopamine and acetylcholine in CSF. RBD is an independent influencing factor of overall olfactory function and discrimination, and the decreased acetylcholine level in CSF may be the common neurobiochemical basis of RBD and OD in PD patients.