Soliton Dynamics and DDMC/sncRNAs Complex for Epigenetic Change to Normal Cells in TME

Complex by DDMC/sncRNAs(a-miR-155, piR-30074, and miR-125b) have shown the full recovery of mice from virus-induced sarcoma after treatment by changing to normal cells from cancer cells. With kinetic of inhibiting tumor growth, the difference from control (mm^2) of one intravenous injection and two intravenous injections is the same curvature and rate so that this is a soliton wave having a permanent form (velocity, shape) such as one faster soliton overcoming another one without any changing shape in the case of two intravenous injections. Signal transduction for this DDS must be Hill-type sigmoids following the nonlinear Schrödinger model by transfer of energy, sine-Gordon soliton model by momentum, and Fisher KPP soliton model by mass transfer. We find out that the cell outlet/inlet response of DDMC/sncRNAs is more dependent on the soliton signal not losing energy and shape without jamming communication. The endoplasmic reticulum-mitochondrial Ca^2+ fluxes induced by soliton to Chromosome in nuclear will take place epigenetic modifications on 5-position of cytosine (5mC) by TET enzymes and thymine DNA glycosylase (TDG) as an overall intracellular reaction. By soliton flow, the result shows the equations of quantum mechanics can be related to the epigenetic control with Ca^2+ fluxes followed by “induced fit model” Hill equation S-shaped.