小儿麻龙止咳平喘颗粒对过敏性咳嗽的治疗作用

Objective To evaluate the effectiveness of Xiaoer Malong Zhike Pingchuan Granule(小儿麻龙止咳平喘颗粒)in treating allergic cough in children.Methods Allergic cough in guinea pigs,cough induced by ammonia water in mice and cough induced by citric acid in guinea pigs were used to investigate the antitussive effect of the drug;The antiasthmatic effect of drug was investigated in guinea pig asthma model induced by histamine and isolated guinea pig trachea;The expectorant effect was evaluated by phenol red test in mice;Passive cutaneous anaphylaxis in rats was used to investigate the antiallergic effect of drugs.Results Continuous administration of 9.0,18.0 g/kg Xiaoer Malong Zhike Pingchuan Granule for 7 d significantly prolonged the cough latency of allergic cough guinea pigs(P＜0.05,0.01),and significantly reduced the number of coughs(P＜0.05,0.01);The continuous administration of 7.50,15.00,30.00 g/kg Xiaoer Malong Zhike Pingchuan Granule for 3 d significantly reduced the number of coughs caused by ammonia in mice(P＜0.01);Continuous administration of 9.0,18.0 g/kg Xiaoer Malong Zhike Pingchuan Granule for 3 d significantly prolonged the cough latency caused by citric acid in guinea pigs(P＜0.05),significantly reduced the number of coughs(P＜0.05,0.01),and significantly prolonged the latency caused by histamine induced asthma in guinea pigs(P＜0.05,0.01);The median effective dose(ED50)for antagonizing histamine induced isolated tracheal spasm in guinea pigs was 0.123g/kg.Continuous administration of 7.50,15.00 g/kg Xiaoer Malong Zhike Pingchuan Granule for 3 d significantly increased the excretion of phenol red in the trachea of mice(P＜0.05,0.01);Continuous administration of 5.0,10.0 g/kg Xiaoer Malong Zhike Pingchuan Granule for 7 d significantly reduced the diameter of the blue spot on the skin of rats(P＜0.05),and decreased the absorbance(P＜0.05,0.01).Conclusion Xiaoer Malong Zhike Pingchuan Granule has obvious cough relieving,asthma relieving,expectorant,and anti-allergic effects,and has a significant therapeutic effect on allergic cough.