The use of microwave radiations and propylphosphonic anhydride (T3P?) for rapid and highly yielding amide bond formation and peptide coupling

An improved, fast, and efficient procedure for amide bond formation and peptide coupling is reported leading to the expected corresponding derivatives in good to excellent isolated yields ranging from 26 to 90%. The outcome of the reaction was also investigated in relation to the influence of different parameters such as the nature of the solvent, the temperature as well as the amine/carboxylic acid couple involved or the hydrolysis conditions.