Structurally diverse stilbenes from Gnetum parvifolium and their anti-neuroinflammatory activities
BIOORGANIC CHEMISTRY(2024)
摘要
Phytochemical investigation on the aerial parts of Gnetum parvifolium led to the isolation of 15 new and eight known structurally diverse stilbenes. The isolated compounds comprised (E)-or (Z)-stilbene (1-6, 15-20), dihydrostilbene (21), phenylbenzofuran (7, 8, 22), benzylated stilbene (9-11), benzylated stilbene dimer (12), and nitrogen-containing stilbene (13a, 13b, 14) types. The structures of the new compounds (1-12, 13a, 13b, 14) were established through spectroscopic analyses and experimental and calculated ECD data. Compound 12 is the first stilbene dimer connected through a benzyl group. In the anti-neuroinflammatory activity assay, com-pounds 4, 5, 9-11, 13b, and 16-21 displayed significant inhibitory effects against LPS-induced NO release in BV -2 microglial cells, with IC50 values of 0.35-16.1 mu M. Compound 10 had the most potent activity (IC50 = 0.35 mu M), and the further research indicated that it could decrease the mRNA levels of iNOS, IL-1 beta, IL-6, and TNF-alpha in a dose-dependent manner.
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关键词
Gnetum parvifolium,Gnetaceae,Stilbenoids,Anti-neuroinflammatory
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