Remodulatory effects of coral fossil on hematobiochemical parameters and histoaccumulation of specific organs in lead intoxicated broilers

Objectives: The research aims to assess the impact of coral fossil (CF) on hematobiochemical parameters, organ's accumulation, and remodulation in lead (Pb) intoxicated broiler birds.Methods: 45 broilers were used in the experiment, which was divided into 03 groups, each of which contained 15 broilers. The control group was Group A. Pb (280 mg/kg b. w.) was administered orally to the birds in group B. Group C received Pb (280 mg/kg b.w.) and CF (1 gm/kg b.w.) oral supplements. The research was carried out for 30 days. Blood samples were collected, and sera were prepared for biochemical analysis. Pb accumulation concentration was assessed in muscle, liver and kidney. Moreover, samples of the brain, liver, and kidneys were obtained and prepared for histological analysis.Results: Pb affected hematological markers (Total RBC, Hb conc., hematocrit value, differential leukocytes and blood indices), which were restored with CF supplementation. In Pb-treated broilers, hepatic enzymes (AST, ALT), renal biomarkers (creatinine, total protein and albumin) and lipid profile (TC, TG, HDL and LDL) increased substantially (p < 0.05), but dropped significantly (p < 0.05) after CF supplementation. Pb accumulation was higher in liver, kidney and muscle tissue that was reduced by CF treatment. The histopathological study demonstrated that there was accumulation of fluid around in brain, hyperplasia of bile duct and glomerular epithelium in Pb intoxicated broilers and these were restored after CF supplementation.Conclusions: Therefore, it can be concluded that CF supplementation restored the lead induced detrimental effects on broilers. So, CF has remodulatory effects on Pb toxicity.