Association between nesfatin-1 hormone levels, anthropometric measurements, and glucose regulation shortly after sleeve gastrectomy: A cross-sectional study

Objective This cross-sectional study was planned to evaluate the relationship between serum nesfatin-1 levels, glucose regulation and anthropometric measurements of individuals who had undergone sleeve gastrectomy. Methods A total of 40 participants aged between 19 and 64 years with a body mass index (BMI) greater than 30 kg/m 2 who underwent sleeve gastrectomy participated in the study. Before and 1 month after the surgery, serum nesfatin-1, fasting insulin levels, anthropometric measurements and biochemical parameters were assessed. Results Serum nesfatin-1 levels significantly decreased 4 weeks after the surgery (108.3 ± 58.35 pg/mL versus 74.6 ± 40.12 pg/mL: p = 0.003). Serum insulin levels (µIU/ml) showed a similar decrease ( p < 0.001). Change in serum nesfatin-1 levels significantly correlated with change in BMI and body fat mass ( p = 0.009, p = 0.007, respectively). Furthermore, serum nesfatin-1 levels significantly correlated with total cholesterol levels ( p = 0.037). However, despite the significant decreases in both nesfatin-1 levels and glucose regulation markers, no correlation was found between them. The significant decrease observed in post-operative serum nesfatin-1 levels was found to be correlated with anthropometric measurements. Conclusions This finding highlights the anorexigenic effects of nesfatin-1, and therefore, nesfatin-1 may be an effective factor in obesity treatment and diabetes.