Antibacterial Potentialities of Chitosan Nanoparticles Loaded with Salvianolic Acid B and Tanshinone IIA

This study describes the preparation, physicochemical characterization, controlled release, and bioavailability of chitosan nanoparticles (CTSNPs) loaded with salvianolic acid B (SlB) and tanshinone IIA (TnA). It also aimed to assess their antibacterial activity against foodborne pathogen. SlB and TnA were loaded on CTSNPs with ionic gelation method. They were then in vitro characterized via infrared and electron microscopy. SlB/TnA/CTSNPs showed excellent colloidal properties (size 129.3 nm and zeta-potential + 31.8 mV); the encapsulation efficiency (EE) of SlB/CTSNPs and TnA/CTSNPs was 51.43 and 88.36