Design, Synthesis, and Biological Activity of Novel 1,3,5-Triazine–1,2,4-Triazine Hybrids as Cholinesterase Inhibitors

Chang-E. Dong,Rui Li, Zai-Xiu Pan,He Li,Jing-Jing Qian,Wei-Wei Liu,Zhi-Ling Cao,Da-Hua Shi

Russian Journal of Organic Chemistry（2023）

引用 0|浏览0

暂无评分

摘要

Fourteen 1,3,5-triazine–1,2,4-triazine hybrids were designed and synthesized. Their structures were confirmed by IR, NMR, and high-resolution mass spectra, as well as by single crystal X-ray diffraction. The cholinesterase inhibitory activities of the hybrids were assayed by Ellman’s method. Five of the fourteen hybrids inhibited acetylcholinesterase by more than 50

查看译文

关键词

Alzheimer disease,acetylcholinesterase,butyrylcholinesterase,1,3,5-triazine,1,2,4-triazine

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要