Studies of normal human osteoblasts and fibroblasts growth on composite functionalized β-type Ti23Zr25Nb (at

This study aims to present biological studies of ultrafine-grained Ti-based materials with niobium and zirconium content, and additionally modified with 45S5 bioglass and silver—Ti23Zr25Nb-9BG-Ag. Alloy and composites with 45S5 bioglass and silver were produced with the mechanical alloying approach. The in vitro cytocompatibility of these biomaterials was evaluated and compared with conventional microcrystalline titanium. During the studies, established cell lines of normal human periodontal ligament fibroblasts (HPdLF, CC-7049) and normal human osteoblasts (NHost, CC-2538) were cultured in the presence of tested materials, and their survival rate and proliferation activity were examined. Ti23Zr25Nb (at