Non-coding RNAs and Aquaporin 4: Their Role in the Pathogenesis of Neurological Disorders

Zahra Yaghoobi, Shahrzad Sadat Seyed Bagher Nazeri, Amir Asadi, Ehsan Derafsh, Abdolkarim Talebi Taheri, Zeinab Tamtaji,Ehsan Dadgostar, Fatemeh Rahmati-Dehkordi,Michael Aschner,Hamed Mirzaei,Omid Reza Tamtaji,Fatemeh Nabavizadeh

Neurochemical Research（2024）

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摘要

Neurological disorders are a major group of non-communicable diseases affecting quality of life. Non-Coding RNAs (ncRNAs) have an important role in the etiology of neurological disorders. In studies on the genesis of neurological diseases, aquaporin 4 (AQP4) expression and activity have both been linked to ncRNAs. The upregulation or downregulation of several ncRNAs leads to neurological disorder progression by targeting AQP4. The role of ncRNAs and AQP4 in neurological disorders is discussed in this review.

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关键词

Neurological disorders,Aquaporin-4,Non-coding RNAs,microRNA,Long non-coding RNA

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