Rictor mediates p53 deactivation to facilitate the malignant transformation of hepatocytes and promote hepatocarcinogenesis

Chun Wang, Hui Kang,Yun Yi,Yang Ding,Fan Wang,Jie Luo,Mingliang Ye,Yinghui Hong,Chao Xia,Junwei Yan,Lan Liu,Jing Liu,Zibiao Zhong,Zhonglin Zhang,Qiu Zhao,Ying Chang

Journal of Translational Medicine（2023）

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摘要

Mutations in TP53 gene is considered a main driver of hepatocellular carcinoma (HCC). While TP53 mutations are the leading cause of p53 dysfunction, their occurrence rates may drop to approximately 10

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关键词

Hepatocellular carcinoma,Rictor,TP53,microRNA-192,Nucleocytoplasmic shuttle,Wild-type,Mutant

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