The gut microbiota in adults with cystic fibrosis compared to colorectal cancer

L.R. Caley, H.M. Wood, D. Bottomley, A. Fuentes Balaguer, L. Wilkinson, J. Dyson,C. Young,H. White, S Benton, M. Brearley, P. Quirke,D.G. Peckham

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society（2023）

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摘要

•People with cystic fibrosis (pwCF) have gut dysbiosis (imbalanced microbiota).•Gut dysbiosis is reported in people with colorectal cancer (pwCRC).•CF stool microbiota is distinct compared to pwCRC and controls.•Certain CRC-associated bacteria are increased in CF stool samples.•Other apparently beneficial bacteria are decreased in CF stool samples.

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关键词

Colorectal cancer,Cystic fibrosis,Gut microbiota,CFTR modulators,Dysbiosis

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