Surgical microwave ablation for the treatment of hepatocellular carcinoma in 791 operations

Introduction: Hepatocellular carcinoma (HCC) is a leading cause of cancer -related mortality and often arises in the setting of cirrhosis. The present series reviews outcomes following 791 operations. Methods: Retrospective review surgical MWA for HCC from March 2007 through December 2022 at a high -volume institution was performed using a prospective database. Primary outcome was overall survival. Results: A total of 791 operations in 623 patients and 1156 HCC tumors were treated with surgical MWA. Median tumor size was 2 cm (range 0.25-10 cm) with an average of 1 tumor ablated per operation (range 1-7 tumors). Nearly 90 % of patients had cirrhosis with a median MELD score of 8 (IQR = 6-11). Mortality within 30 days occurred in 13 patients (1.6 %). Per tumor, the rate of incomplete ablation was 2.25 % and local recurrence was 2.95 %. Previous ablation and tumor size were risk factors for recurrence. One-year overall survival was 82.0 % with a median overall survival of 36.5 months (95 % CI 15.7-93.7) and median disease -free survival of 15.9 months (range 5.7-37.3 months). Conclusion: Surgical MWA offers a low -morbidity approach for treatment of HCC, affording low rates of incomplete ablation and local recurrence.