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Sugar-free synapses run on mitochondrial Sirtuin 3.

Alexander P Walsh,David J Simon

The Journal of cell biology（2023）

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Abstract
Metabolic plasticity of neurons ensures their activity continues when glucose is limited. Walsh and Simon discuss new work by Ashrafi and colleagues (https://doi.org/10.1083/jcb.202305048) that finds Sirtuin 3 directs local metabolic adaptation at synapses during sustained glucose deprivation.
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