Extravascular Factor IX Pool Fed By Prophylaxis Is a True Hemostatic Barrier Against Bleeding
BLOOD(2023)
摘要
Taken together, these results show that in individuals with severe hemophilia B receiving regular prophylaxis with FIX, extravascular accumulation of FIX over time may have a significant impact on the coagulation capacity and protection towards bleeding.
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关键词
collagen I,collagen IV,extravascular FIX,hemophilia B,joint,liver,saphenous vein bleeding model
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