Development and validation of an LC-MS/MS method for the quantification of KRASG12C inhibitor opnurasib in several mouse matrices and its application in a pharmacokinetic mouse study
Journal of Chromatography B（2024）
Abstract
•First developed bioanalytical assay for opnurasib in nine different mouse matrices.•LC-MS/MS method with protein precipitation has been successfully validated.•The assay was successfully applied for pharmacokinetic pilot study in mice.
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Key words
Opnurasib,KRASG12C inhibitor,LC-MS/MS,Bioanalysis,Mouse matrices
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