Monkeypox virus (MPXV): A Brief account of global spread, epidemiology, virology, clinical features, pathogenesis, and therapeutic interventions

•The largest 2022 Monkeypox (MPX) outbreak has changed its nature rather than earlier including clinical signs symptoms, severity, and epidemiology.•MPX occurrences are declining; however, awareness must be raised on this contagious disease to stop further outbreaks.•More research-based studies need to be carried out to find our virus morphology, its genomics, mode of transmission, reservoirs, and therapeutic treatment.