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Mapping the genetic and phenotypic landscape of neonatal C3 and C4 protein concentrations

Leanna M. Hernandez

CELL GENOMICS（2023）

Cited 0|Views7
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Abstract
The complement system is crucial for innate immunity and has been linked to autoimmune and psychiatric disorders. Borbye-Lorenzen et al.(1) perform GWASs and PheWASs of neonatal C3/C4 protein concentrations, finding multiple genome-wide significant loci, and identify sex-specific associations between C3 protein concentration and C4 copy number with risk for schizophrenia.
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