C5a enhances inflammation and chemotaxis of γδ T cells in malignant pleural effusion

Shuanglinzi Deng, Yuanyuan Jiang,Lisha Luo, Huan Tang, Xinyue Hu,Chendong Wu,Jiale Tang,Huan Ge, Xiaoxiao Gong, Runjin Cai,Guo Wang, Xiaozhao Li,Juntao Feng

International Immunopharmacology（2024）

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摘要

•γδ T cells infiltrate malignant pleural effusion (MPE) and exhibit high cytotoxicity.•The recruitment of γδ T cells to the pleural cavity in MPE is facilitated by CCL2-CCR2 axis.•C5a enhances the cytotoxicity and chemotaxis of γδ T cells in MPE.•Targeting γδ T cells, especially Vδ2 cells, to revitalize the cytotoxic of them holds promise for control of MPE.

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