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Clinical features and outcomes of advanced HER2+ esophageal/GEJ cancer with brain metastasis

K. Liang,J.L. Feliciano,K.A. Marrone, J.C. Murray, C.L. Hann,V. Anagnostou, S.A. Tackett, E.J. Shin,R.K. Hales,K.R. Voong,R.J. Battafarano, S.C. Yang,S.R. Broderick, J.S. Ha,P.M. Forde,J.R. Brahmer,V.K. Lam

ESMO Open(2024)

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Abstract
•HER2 overexpression carries increased BRM risk in E/GEJ cancer.•Trastuzumab therapy improves clinical outcomes in HER2+ E/GEJ patients with BRM.•Prevalence of solitary/asymptomatic BRMs suggests role for enhanced surveillance.
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Key words
esophageal cancer,gastroesophageal junction cancer,HER2 overexpression,brain metastasis
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