Clinical features and outcomes of advanced HER2+ esophageal/GEJ cancer with brain metastasis
ESMO Open(2024)
Abstract
•HER2 overexpression carries increased BRM risk in E/GEJ cancer.•Trastuzumab therapy improves clinical outcomes in HER2+ E/GEJ patients with BRM.•Prevalence of solitary/asymptomatic BRMs suggests role for enhanced surveillance.
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Key words
esophageal cancer,gastroesophageal junction cancer,HER2 overexpression,brain metastasis
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