RNA m6A methylation and MDSCs: Roles and therapeutic implications for radiotherapy

Emerging evidence suggests that local tumor radiotherapy re-shapes the repertoire of circulating myeloid-derived suppressor cells (MDSCs) and leads to their infiltration into the tumor microen-vironment, which poses a major obstacle for radiotherapy efficacy. Recent findings have identified RNA m6A modification at the nexus of both anti-tumor immunity and radiation response. Here, we examine the mechanisms by which this RNA modification modulates the immune milieu of the radiation-remodeled tumor microenviron-ment. We discuss potential therapeutic interventions targeting m6A machinery to improve radiotherapy response.