Production of pharmaceutical grade [201Tl]Thallous chloride using 30 MeV cyclotron

Sankha Chattopadhyay,Luna Barua,D. G. Mahesh,Shayantani Ash,Arpit Mitra,Sujata Saha Das,Samarjit Singha,Md Neyar Alam, Madhusmita,Suprakash Roy,Prosenjit Dhang,Mukesh Jain

Applied Radiation and Isotopes（2024）

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摘要

Multiple patient doses of [201Tl]TlCl has been produced using electrodeposited enriched 203Tl in 30 MeV cyclotron (Cyclone-30) with 28 MeV proton energy at 50 mu A beam current for 8 h. Ion Exchange Column Chromatography (IECC) and liquid-liquid extraction has been employed for semi-automated radiochemical separation and purification of produced [201Tl]TlCl. The produced [201Tl]TlCl was used in coronary artery disease (CAD) patients.

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关键词

201Tl]TlCl,Pharmacopeia,30 MeV cyclotron,Ischemia,SPECT/CT

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