Aggregates of nonmuscular myosin IIA in erythrocytes associate with GATA1- and GFI1B-related thrombocytopenia

Carlo Zaninetti,Jose’ Rivera,Leonard Vater,Sandra Ohlenforst,Eva Leinøe,Doris Böckelmann,Kathleen Freson,Thomas Thiele,Houssain Makhloufi,Matthias Rath,Wolfgang Eberl,Martina Wolff,Carmen Freyer,Jan Wesche,Barbara Zieger,Ute Felbor,Florian H. Heidel,Andreas Greinacher

Journal of Thrombosis and Haemostasis（2023）

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摘要

Aggregates of NMMIIA in the erythrocytes associate with GATA1-RT and GFI1B-RT and can facilitate their diagnosis on the blood smears. This hitherto unreported finding might represent a novel marker of dyserythropoiesis assessable in peripheral blood.

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blood morphology,blood platelets,erythrocytes,immunofluorescence,inherited thrombocytopenia

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