Diosmin alleviates doxorubicin-induced chemobrain in rats via inhibition of oxido-inflammation, apoptosis and modulation of autophagy
Brain Disorders(2024)
摘要
•Diosmin abates doxorubicin-induced apoptosis in rats testes.•Diosmin abates doxorubicin-induced oxido-inflammation in rats testes.•Diosmin abates doxorubicin-induced autophagy.•Diosmin enhances brain antioxidant enzymes in rats treated with doxorubicin.•Diosmin reversed doxorubicin -induced alteration in metabolic enzymes in rats brain.
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关键词
Chemobrain,Diosmin,Doxorubicin,Inflammation,Oxidative stress,Autophagic flux,Apoptosis
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