Diosmin alleviates doxorubicin-induced chemobrain in rats via inhibition of oxido-inflammation, apoptosis and modulation of autophagy

Oyovwi O. Mega,Falajiki Y. Faith,Ohwin P. Ejiro,Joseph G. Uchechukwu,Olowe G. Temitope,Onome B. Oghenetega,Emojevwe Victor,Tesi P. Edesiri,Rotu A. Rume,Rotu A. Rotu,Oyeleke Abiodun Abioye,Okwute Patrick Godwin

Brain Disorders（2024）

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摘要

•Diosmin abates doxorubicin-induced apoptosis in rats testes.•Diosmin abates doxorubicin-induced oxido-inflammation in rats testes.•Diosmin abates doxorubicin-induced autophagy.•Diosmin enhances brain antioxidant enzymes in rats treated with doxorubicin.•Diosmin reversed doxorubicin -induced alteration in metabolic enzymes in rats brain.

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关键词

Chemobrain,Diosmin,Doxorubicin,Inflammation,Oxidative stress,Autophagic flux,Apoptosis

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