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Long-COVID-19: the persisting imprint of SARS-CoV-2 infections on the innate immune system

Marianne Boes,Pascal Falter-Braun

SIGNAL TRANSDUCTION AND TARGETED THERAPY（2023）

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Abstract
In a recent Cell publication,Cheong et al.uncover how COVID-19 causes IL-6 induced epigenetic reprogramming of human immune stem cells,which causes lasting alterations in the composition and response characteristics of circulating immune cells.1 The study provides important insights into the mechanisms by which SARS-CoV-2 infections impact the human immune system and is an important hook into unraveling the mechanisms of post-acute sequelae of COVID-19(PASC)commonly referred to as long-COVID.
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