The Effect of the Antioxidant System “Resveratrol – Iron Sulfonitrosyl Complex Sodium-μ2-Dithiosulphate-Tetranitrosyl Diferrate Tetrahydrate” on the Mitochondria of Pea Germ Epicotyls in vitro

The interaction of antioxidants, plant polyphenol resveratrol and nitric oxide donor, sulfur nitrosyl iron complex with thiosulfate Na 2 [Fe 2 (S 2 O 3 ) 2 (NO) 4 ] 2 · 4H 2 O (TNIC-thio), and their combined action on the mitochondria of epicotyls of pea seedlings in vitro were studied. The antioxidant activity of resveratrol at a concentration of 10 –6 M partially compensated for the toxic effect of TNIC-thio at high concentrations, which was most likely due to the manifestation of the pro-oxidant properties of high concentrations of the nitric oxide donor. The effect of resveratrol at concentrations of 10 –6 and 10 –8 M on the membranes of mitochondria isolated from the epicotyls of pea seedlings in the presence of 10 –8 M TNIC-thio led to a violation of the regulation system of lipid peroxidation of membranes, which caused antioxidant stress. The effect of resveratrol at a dose of 2 × 10 –5 M was of a dual nature and practically did not affect the structural state of mitochondrial membranes.