Activity of Nonnucleoside Inhibitors of O 6 -methylguanine-DNA Methyltransferase Repair Enzyme in Human Cells In Vitro

K. S. Zhuvaka,G. P. Volynets, T. P. Ruban, Z. M. Nidoeva, A. P. Iatsyshyna, L. L. Macewizc, V. G. Bdzhola,S. M. Yarmoluk,L. L. Lukash

Cytology and Genetics（2023）

引用 0|浏览0

暂无评分

摘要

The repair enzyme O 6 -methylguanine-DNA methyltransferase (MGMT) eliminates alkyl lesions that play the main anticancer role in alkylating chemotherapy. The inhibition of MGMT leads to increasing effectiveness of alkylating chemotherapy. In this study, new potential MGMT inhibitors were tested. It was found that some compounds demonstrate low cytotoxicity and high effectiveness in human cells in vitro .

查看译文

关键词

Repair enzyme MGMT,new potential MGMT inhibitors,alkylating agent,cell line HEp-2

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要